Aging is a central issue in modern scientific research. The scientific community has created over 300 theories to attempt to explain the relationships of aging.
Normal cells have a limited ability to divide. This division also involves DNA replication.
DNA replication is a fundamental process that occurs every time a cell divides. The two daughter cells that are produced must contain exactly the same genetic information, or DNA, as the parent cell. Errors can also occur during the editing mechanisms of the cell, which can be corrected by the cell's DNA repair machinery. The cell selects the repair mechanism based on the type of damage and the timing of the cell cycle. Some of the errors are corrected immediately during replication so that replication can continue. Other errors are corrected after replication by another repair process in the cell.
If DNA cannot be repaired, the repair machinery attempts to minimize the damage to ensure the viability of the cell. Any decline in the mammalian DNA repair capacity is associated with cellular aging.
If we look a little closer at this DNA replication, there is one more thing worth highlighting: the DNA in the cell nucleus is packaged into chromosomes, and the ends of the chromosomes are capped by so-called telomeres. Think of it as a string with beads at certain points. This string shortens each time the cell replicates. This continues until the imaginary string of beads becomes so short that the cell can no longer divide. The telomere – or the bead in our analogy – maintains chromosome integrity and genetic stability in cells. Changes in telomere length are often associated with lifestyle factors such as age, obesity, exposure to environmental pollution, depression, unhealthy diet, lack of exercise, or stress.
A study was recently published by Hungarian researchers, including the scientific director of our Center, investigating whether there is a connection between telomere shortening and an active, sporty lifestyle. In this article, the researchers pointed out that it cannot be ruled out that people who lead more active lives also age more slowly.
The beauty industry has developed a number of new solutions designed to reduce the visible signs of aging on the skin. These technologies offer solutions for all skin types, of almost all ages.
One thing is certain: biological aging cannot be stopped, but we can do a lot to be healthy and beautiful inside and out.
We are happy to help you with our constantly expanding range.
We also welcome applications from young researchers who would like to join our beauty industry research. Details in the Our Research menu: https://awcosmetics.hu/kutatasaink/
The AW Cosmetics Team
Source: Alsabeelah, N., Arshad, MF, Hashmi, S., Khan, RA, & Khan, S. (2021). Nanocosmeceuticals for the management of aging: Rigors and Vigors. Journal of Drug Delivery Science and Technology, 63, 102448.
Hochstrasser, T., Marksteiner, J., & Humpel, C. (2012). Telomere length is age-dependent and reduced in monocytes of Alzheimer patients. Experimental gerontology, 47(2), 160-163.
Verma, AK, Singh, P., Al-Saeed, FA, Ahmed, AE, Kumar, S., Kumar, A., … & Dohare, R. (2022). Unraveling the role of telomere shortening with aging and their potential association with diabetes, cancer, and related lifestyle factors. Tissue and Cell, 101925.
Seki, Y., Aczel, D., Torma, F., Jokai, M., Boros, A., Suzuki, K., ... & Radak, Z. (2023). No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging. Biogerontology, 1-11.https://m2.mtmt.hu/gui2/?mode=search&query=publication;labelOrMtid;eq;No%20strong%20association%20among%20epigenetic%20modifications%20by%20DNA%20methylation%2C%20telomere%20length%2C%20and%20physical%20fitness%20in%20biological%20aging
Ignatieva, LN, Mashchenko, VA, Kiryukhin, DP, Kichigina, GA, Kushch, PP, & Bouznik, VM (2021). Tetrafluoroethylene telomeres obtained by radiation-chemical synthesis with various telogens. Journal of Fluorine Chemistry, 242, 109699.
Wolf, A. M. (2021). The tumor suppression theory of aging. Mechanisms of Aging and Development, 200, 111583.
